Fagerson out because of a back spasm.
Tadhg Furlong has been drafted into the Lions starting 15 to face Japan at Murrayfield on Saturday.
Zander Fagerson had been due to play but is suffering from a back spasm.
That means all seven Irish players included in Warren Gatland's squad will start the first-warm up game.
The change means that all seven Irish players in the squad start Saturday’s first warm-up match in Edinburgh.https://t.co/qBVtWu9Wik via @IrishTimesSport
— Irish Times Sport (@IrishTimesSport) June 24, 2021