The HSE said many of the assaults involved multiple attackers.
24 children under the age of 14 presented at Sexual Assault Treatment Units last year, after being attacked, a total of 102 were under the age of 16.
In total, 859 patients attended the HSE's six Sexual Assault Treatment Units in 2021 - an increase of 17% on the previous year.
There were multiple attackers in around 43 of the crimes.
While the average age of the victims was 26, 24 were less than 14, and 78 were between 14 and 16.
Some 42% of those treated in the units last year had consumed more than six standard alcohol drinks.
92% of those who presented at sexual assault treatment units last year, were female.
Cliona Sadlier is the executive director of the Rape Crisis Network Ireland said the figures are very concerning:

National Homelessness Figures Drop For First Time In Months, With Decrease Also Seen In Kildare
Report Finds Improvement In Inpatient Mental Health Services
Status Yellow Thunderstorm Warning For Kildare And Other Counties Today
Man Accused Of Woman's Murder Near IPAS Centre Dies In Prison
Temperature Warning Extended Until Saturday
Ireland Could See Hottest Day In 140 Years Today
Kildare Minister Says Ireland Is At "Critical Moment" In Relation To AI
Almost 20,000 Commuters Affected By Major Rail Disruption This Morning