This includes jobs in human resources and engineering divisions
Microsoft is cutting 10,000 workers - almost 5% of its global workforce.
In another massive blow to the tech industry, the multi-million dollar company, which employs around 3,500 people in Ireland.
This could lead to around 175 job losses at its Leixlip and Leopardstown offices, where 3,500 people are employed.
This includes jobs in human resources and engineering divisions.
The software and PC giant laid off a small number of employees in July last year.
After sales plummeted for Windows and Microsoft devices, Microsoft is working to maintain growth rates at its cloud unit Azure.
In a note to staff, the company chairman thanked employees and said Microsoft will continue to hire in certain departments.

Meath Bird Flu Case Prompts Warning, But Chicken And Turkey Safe To Eat, Says Agriculture Minister
One-Month Road Closure In Catherinestown To Start Next Week To Facilitate Maynooth Pipeline Works
Commuter Chaos On M7/N7 Renews Calls For Standby Emergency Response Team During Morning Gridlock
Thousands Of Workers Could Get Tax Back In Time For Christmas, Says Financial Advisor
Tension In Fianna Fáil Over Alleged Rebel List, With Kildare TD Sean Ó Fearghaíl Labelled Part Of Old Guard
Exclusive: Cllr Bill Clear To Join Independent Ireland After Months Of Discussions
WATCH: Car Linked To Attempted Naas Robbery Spotted In Newcastle - Gardaí Warn Public Not To Approach
Gardai Appeal To Public For Assistance In Attempted Burlgary At Osprey Car Park Naas