Both sides are away from home.
Manchester United manager Ole Gunnar Solskjaer says he can take the heat as he prepares to lead his players into a Champions League tie with Atalanta in Italy tonight.
The Group F encounter kicks off at 8.
Paul Pogba could feature.
Solskjaer says getting stick is part of the territory.
Elswhere in the Group, Villarreal take on Young Boys.
In Group H, Chelsea are away to Malmo, with that match kicking off at 5.45 in Sweden.
The other game in that group sees Juventus play Zenit Saint Petersburg.
In Group E, Barcelona are in Ukraine to face Dynamo Kiev, while Bayern Munich take on Benfica.
In Group G, it's Wolfsburg versus Red Bull Salzburg,
And Sevilla to face Lille.
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