Mr Reid has said he has no immediate career plans.
HSE Chief Executive Paul Reid has announced that he will be stepping down from his position later this year.
Mr Reid will step down in December, saying he has no immediate career plans.
He has agreed to leave later in the year, to allow time to find his successor.
Mr Reid said his decision was influenced by a desire to spend more time with his family, and a "belief that the HSE was entering a new phase and that the appointment of a new leader was now timely".
In a message to HSE staff, Paul Reid said he is making the decision with a heavy heart, and it was the hardest decision he has ever made in his career.
Minister for Health, Stephen Donnelly TD commented: "Since his appointment as Chief Executive in June 2019, Paul Reid has provided exemplary leadership to the HSE.
“He has led Ireland’s health service through some of its most difficult days and has done so with dedication and professionalism.
“Throughout the pandemic, Paul played a critical role in leading Ireland’s response to the greatest health emergency of our times.
“He leaves behind him an organisation much enhanced for his time as Chief Executive and one that is already making real progress in implementing reform and improvement across many aspects of healthcare provision.
“I want to wish Paul all the best for the time ahead and to thank him and his family for the many sacrifices they have made over the last three years to allow him to dedicate himself to the role of CEO,” he added.
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