Dozens of White House officials are also making the trip.
US President Joe Biden will arrive in Belfast tonight ahead of a three-day visit to the island of Ireland.
Air Force One is expected to touch down at Belfast International Airport shortly after 9pm.
Mr Biden will be greeted and welcomed to Northern Ireland by British Prime Minister Rishi Sunak.
The entourage travelling with him will include US Secretary of State Antony Blinken and the recently appointed US Special Economic Envoy to Northern Ireland Joseph Kennedy III.
Dozens of White House officials are also making the trip.
Mr Biden is expected to leave Belfast at around 2pm tomorrow to travel across the border for three days of engagements in Dublin, Louth and Mayo.

Ryder Cup Ticket Rush As Irish Fans Get First Access to Adare 2027
Focus Ireland Launch New Strategic Plan Amid Record Homeless Figures
Straffan Couple Win Home Of The Year
Broadcast Levy To Increase Costs For Small Radio Stations By Over €14,000 Per Year
Figures Reveal A Drop In Kildare Burglaries
Mother And Campaigner Speaks Out About Uncertainty For Surrogate Parents
Kildare South TD Martin Heydon Has Criticised Leo Varadkar Following His Comments About Rural Ireland
Audit Shows Kildare Senator Had To Repay Some Parliamentary Allowances That Didn't Qualify