Dozens of White House officials are also making the trip.
US President Joe Biden will arrive in Belfast tonight ahead of a three-day visit to the island of Ireland.
Air Force One is expected to touch down at Belfast International Airport shortly after 9pm.
Mr Biden will be greeted and welcomed to Northern Ireland by British Prime Minister Rishi Sunak.
The entourage travelling with him will include US Secretary of State Antony Blinken and the recently appointed US Special Economic Envoy to Northern Ireland Joseph Kennedy III.
Dozens of White House officials are also making the trip.
Mr Biden is expected to leave Belfast at around 2pm tomorrow to travel across the border for three days of engagements in Dublin, Louth and Mayo.

45 Years Later, Payment Of €20,000 Announced For Stardust Survivors
More Than 1,300 Crimes Committed By People On Bail In Kildare/Carlow Last Year
Hundreds Of People In Ireland Died By Suspected Suicide After Contact With Health Services
New Framework To Reform Irish Defence Forces Heads To Cabinet
Six People Including A Child Hospitalised After Arson Attack In Dublin
€1.7 Million Worth Of Drugs Seized In Carlow Town
Overbidding At Auctions Putting Homebuyers Under Intense Pressure
Woman Allegedly Attacked With Weapon After Being Ordered To Delete Photo Of Attempted Break-In