Andy Farrell named the side earlier.
Garry Ringrose is out of Ireland's opening match of this year's Six Nations with a shoulder injury.
The centre has returned home from the Quinta do Lago training camp - carrying the knock suffered with Leinster earlier this month.
Lock Joe McCarthy and winger Calvin Nash will make their first competition starts in Marseille on Friday night.
Head coach Andy Farrell's made four changes to the team that started the World Cup defeat to New Zealand.
Nash takes Mack Hansen's spot on the wing in a back three with James Lowe and Hugo Keenan.
Robbie Henshaw comes in for Ringrose to partner Bundee Aki in the centre.
Jamison Gibson-Park has a new partner in the half-back line in the shape of Jack Crowley.
McCarthy replaces Iain Henderson in the second row alongside Tadhg Beirne.
The front and back rows are unchanged with number six Peter O'Mahony skippering the side.