Leinster’s Tommy O’Brien recover's from a back issue and Calvin Nash already ruled out.
Mack Hansen is a doubt for Ireland's opening November international with New Zealand on Saturday.
The wing injured his leg in scoring a try for Connacht in their loss to the Bulls in the URC at the weekend.
Leinster's Tommy O'Brien is currently recovering from a back issue and Munster's Calvin Nash has already been ruled out of the game in Chicago with a shoulder injury.

Alcaraz Withdraws From Wimbledon Due To Wrist Injury
Graeme McDowell To Make His First Major Appearance In Six Years Next Month
Three Of The Irish Provinces To Kick Off The New Season At Home In September
Tuesday Morning Sports Update
All Ireland Football Championship Opening Round Fixtures Confirmed
Tommy O'Brien Among Injury Doubts For Leinster's Champion Cup Final On Saturday
Monday Morning Sports Update
Sunday Evening Sports Update