Eadestown's Jimmy O'Brien is among the replacements.
Andy Farrell has made three changes to the Ireland team that plays England in the Six Nations on Saturday.
Robbie Henshaw and Ryan Baird come in for injured pair Garry Ringrose and Iain Henderson.
The other switch sees Jamison Gibson-Park make his first start of the competition, with Conor Murray on the bench.
Dan Sheehan keeps his place at hooker, despite suffering a shoulder problem in the win over Scotland, but Ronan Kelleher is ruled out with Rob Herring among the replacements.
Eadestown's Jimmy O'Brien is also on the bench.
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