Curry's claim that he was abused by South Africa's Mbonambi is being investigated by World Rugby.
Elsewhere Marcus Smith comes in at full-back and Henry Arundell is on the wing as two of eight new starters.
Scrum-half Ben Youngs makes his first start of the tournament.
Sam Underhill makes his first appearance of the tournament after being called up to the squad as a replacement for Jack Willis during the pool stages.
Owen Farrell continues at fly-half, while coach Steve Borthwick opts for an all-new front row of Ellis Genge, Theo Dan and Will Stuart.
Ollie Chessum displaces George Martin in the second row to pack down alongside Maro Itoje.
The ROI Under 17's Suffer A Disappointing End To Their World Cup Campaign Today
Tuesday Afternoon Sports Update
Tuesday Morning Sports Update
Ulster's Stuart McCloskey Won't Take Part In Game Against South Africa
Luke Littler Is Darts New World Number One
Antony Joshua To Face Jake Paul In A Heavyweight Bout On December 19th
Football Fans Still On A High After Ireland's World Cup Qualifier Win
Monday Morning Golf Update
