Newcastle, Brentford, Man United and West Ham are all in action.
Two other clubs with Champions League ambitions are in action tonight.
Manchester United, who lie fifth, host Brentford at Old Trafford.
Casemiro remains suspended for Man United, who have failed to win any of their last three Premier League games.
Third placed Newcastle United go to the London Stadium to play West Ham United.
Both of those matches kick off at 8pm.

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