Motorists travelling from Kildare via the N7 and the N4 are being advised to expect disruption.
A section of the M50 southbound is closed this morning following a serious two-vehicle collision.
The crash happened between Junction 11 Tallaght and Junction 12 Firhouse at around 5.30am.
A number of people were seriously injured and have been taken to hospital for treatment.
The southbound carriageway remains closed between the two junctions, with diversions in place.
Motorists travelling from Kildare via the N7 and the N4 are being advised to expect disruption.
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