The HSE has confirmed.
The Health Service Executive has confirmed that a child who was being treated for an acute form of hepatitis, has died.
A second child who was also being treated for the same illness has received a liver transplant.
Both cases are being linked to an unexplained type of hepatitis that is being reported in children worldwide.
It's one of six cases of the illness identified in Ireland over the past 10 weeks.
The children range in age from 1 to 12.
Investigations are ongoing to identify the cause of these illnesses.
According to WHO at least 169 cases of acute hepatitis in children have been reported in the UK, EU and the USA.
Worldwide, the WHO says at least 348 cases of acute hepatitis in children have been reported in 20 countries.
Researchers are investigating if the liver disease is linked to Adenovirus, which usually causes a flu-like illness.
Parents are being told to contact their GP immediately if their child shows any signs of hepatitis, including dark urine, pale or grey-coloured poo, or any signs of jaundice, such as yellowing of the eyes or skin.
Consultant Endocrinologist at Bon Secours Hospital Limerick Dr Mary Ryan, says investigations are still ongoing to identify the cause of these illnesses: