He will leave the job at the end of he month.
The Department of Health has confirmed that Dr. Ronan Glynn is stepping down as Assistant Chief Medical Officer.
He has resigned his position and will leave the job on May 31st.
No news is yet available as to his successor.
The Taoiseach has thanked the Deputy CMO for his outstanding service to the Irish people.
Michael Martin says he worked very well with Dr Glynn throughout the pandemic.
He says his unstinting, dedicated and tireless work in fighting COVID-19 was so important to the health and wellbeing of the nation.
In a statement, the Taoiseach said he personifies the very best of Irish public service, and wished him well in the future.
This follows Dr Tony Holohan’s resignation as Chief Medical Officer early last month following controversy surrounding his secondment to a Professorial role at Trinity College Dublin.
Dr Holohan will resign from his role as CMO in July.

Two People Killed In Separate Overnight Road Crashes
Gardaí Travel to Jordan After Arrest in Jamey Carney Case
“You Don't Use A Sledgehammer To Crack A Walnut": Kildare Solicitor Criticises New Legal Aid Scheme As Work Stoppage Continues In Dublin
Nine Critical Infrastructure Projects Designated By Government
Two Arrested Following Interception Of Car Bomb In Monaghan
Nationwide Hosepipe Ban In Place From Today
Nine Infrastructure Projects To Be Fast-Tracked Under New Proposed Legislation
Fuel At The Pump Could Reach €2.30/L If Middle East Conflict Continues