Andy Farrell named the side earlier.
Garry Ringrose is out of Ireland's opening match of this year's Six Nations with a shoulder injury.
The centre has returned home from the Quinta do Lago training camp - carrying the knock suffered with Leinster earlier this month.
Lock Joe McCarthy and winger Calvin Nash will make their first competition starts in Marseille on Friday night.
Head coach Andy Farrell's made four changes to the team that started the World Cup defeat to New Zealand.
Nash takes Mack Hansen's spot on the wing in a back three with James Lowe and Hugo Keenan.
Robbie Henshaw comes in for Ringrose to partner Bundee Aki in the centre.
Jamison Gibson-Park has a new partner in the half-back line in the shape of Jack Crowley.
McCarthy replaces Iain Henderson in the second row alongside Tadhg Beirne.
The front and back rows are unchanged with number six Peter O'Mahony skippering the side.
Kellie Harrington Ruled Out Of Upcoming European Boxing Championships
Shane Lowry Returns To The Top 50 Of Golf's World Rankings
Shane O'Donnell Set To Retire From Club Hurling At The End Of The Season
Monday Morning Sports Update
Weekend UPMC Cub Hurling & Cúl Sliotars Camogie C'ship Results
Garcia Stops Benn In Two Rounds To Claim WBC Welterweight Title
Arsenal's Perfect Record Stays With Win At Sunderland
South Africa Seal Rugby Series Win Over New Zealand With Baltimore Victory
