The Wales full back has made 101 appearances for his country and played four tests for the British and Irish Lions
The Welsh rugby union player's final game will be against the Barbarians in November.
In a statement, Halfpenny said: 'After having time to reflect after the Rugby World Cup campaign, it’s with a heavy heart that I’ve decided it’s time for me to step away from international rugby'.
Thursday Evening Rugby Update
Leinster play Ulster at the Aviva Stadium tomorrow, while Munster made six changes to their side for Saturday's clash.
Thursday Morning Sports Update
Keeping you up to date on soccer, darts, and awards.
Former Liverpool And Blackburn Full-Back Inge Bjornebye Joins Rangers As Football Consultant And Advisor
He join the Scottish Premiership club on an initial deal of around six months.
Lizzy Kent Appointed FAI's New Head Of Women And Girls Football
Kent - who holds a UEFA 'A' Licence - succeeds Hannah Dingley in the role.
No Afternoon Session At The PDC World Darts Championship Today
However, there are four matches down for decision tonight.
Wednesday Morning Sports Update
Keeping you up to date on soccer, darts, boxing and racing.
Tuesday Morning Sports Update
Keeping you up to date on soccer, darts and snooker.
Niall Kelly Retires From Inter County Football
He made 101 appearances scoring 14-138.
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