Darragh Murray and Josh Murphy make their 50th appearances for the province.
Connacht head coach Stuart Lancaster makes three changes from the side that lost to Montpellier last weekend.
Hooker Dave Heffernan, scrum-half Matthew Devine and out-half Jack Carty coming into the side after all three returned from injury.
The second row pairing of Darragh Murray and Josh Murphy make their 50th appearances for the province.
Jack Aungier and Sean Naughton return from injury and are named on the bench.
15. Sam Gilbert (7)
14. Shane Jennings (25)
13. Harry West (5)
12. Cathal Forde (61)
11. Finn Treacy (14)
10. Jack Carty (227)
9. Matthew Devine (26)
1. Billy Bohan (3)
2. Dave Heffernan (227)
3. Sam Illo (38)
4. Darragh Murray (49)
5. Josh Murphy (49)
6. Cian Prendergast (94) (C)
7. Paul Boyle (124)
8. Sean Jansen (36)
16. Dylan Tierney-Martin (65)
17. Denis Buckley (271)
18. Jack Aungier (92)
19. Joe Joyce (45)
20. Sean O’Brien (22)
21. Ben Murphy (25)
22. Sean Naughton (7)
23. Sean Walsh (2)

Curragh Season Opener: Mother's Day, March 15th
Tuesday Morning Sports Update
Hurling New Dissent Rules To Be In Place For National League Finals
Rory McIlroy Confirms Return To Golf Irish Open
Six Nations Trophy To Be Replaced This Year
Irish Squad Back Training As Six Nations Resumes
Monday Morning Sports Update
Kildare LGFA 7 Points Win vs Meath