The collision involved a lorry and two cars.
A woman is believed to be in a critical condition following a multi-vehicle crash in Carlow.
The collision, involving a lorry and two cars, happened at Bang-Up Cross in Tullow at around 1.30pm yesterday afternoon.
A driver of one of the cars, a woman in her fifties, was brought to St Luke's General Hospital for treatment of serious injuries, which are now believed to be critical.
The truck driver, a man in his twenties, and the driver of the other car, a woman in her fourties, were taken to hospital for injuries believed to be non-life-threatening.
The road remains closed this morning for a technical exam, and diversions are in place.
Gardaí are appealing for any witnesses to contact them.

Cabinet Set To Approve New Emergency Broadcast System Today
"Don't Be On Those Red Bulls" : Expert Gives Top Tips As State Exams Begins
Number Of Births Registered In Ireland Declined By Almost 18 Per Cent In Last Ten Years
Report Calls For Fairer Transport System In Ireland
Life Sentence Given To Man Who Murdered His Mother In Cavan
62% Rise In Newly Registered Electric Vehicles In Kildare
Gardaí Investigating Deaths Of Two Young Men In Dublin
Man Dies Following Assault In Dublin City Centre