They were all travelling in a private hire minibus
The PSNI confirmed that three people have died following a road traffic collision on the Tullyvar Road area of Aughnacloy this morning.
Four other people are critically ill in hospital.
They were all travelling in a private hire minibus which was in a collision with a lorry.
It's understood that those traveling on the minibus where on their way to Strabane and had been returning from a funeral in England
The road is closed in both directions and police are asking motorists to avoid the area.
The PSNI have also said they will release a further update this evening.

IFA Protest Targets Minister Heydon's Newbridge Office Over Bord Bia Chair Controversy
Damning Audit Reveals €1.6m Moone-Timolin Cycleway As Safety Time Bomb
Five Kildare Special Schools Included In New Scheme Bringing Therapists Directly Into Schools
Give Gardai Scramblers To Enforce Law On Illegal Bikes, Says Kildare Garda Member
Labour Urges EuroGiant To Give Workers Clarity As Job Fears Grow
Panda Raises Bin Costs In Parts Of The Capital, Leaving Door Open To Wider Hikes Across Leinster
Major Drainage Project Serving Kildare Moves To Early Procurement
Flood Risk Rises In Kildare As Multiple Areas And Routes Close