Victory for Liverpool last night as City lose to PSG.
After their defeat to Young Boys a fortnight ago, Manchester United are in dire need of a win tonight.
They play host to Villareal in a repeat of last season's Europa League final.
United are without the injured Harry Maguire and the suspended Aaron Wan-Bissaka.
Kick-off at Old Trafford is at 8, while the other game in Group F has a 5.45 start.
Young Boys will look to build on that United win when they go to Atalanta.
Chelsea are without N'Golo Kante for tonight's trip to Turin to face Juventus.
The France midfielder has been diagnosed with COVID-19.
Elsewhere in Group H, Zenit St. Petersburg play Malmo.
Lionel Messi produced a vintage goal to open his Paris Saint-Germain account last night.
He scored the second in PSG's 2-0 Champions League to Manchester City.
Elsewhere in Group A, Club Brugge were 2-1 winners away to R-B Leipzig.
Mo Salah and Roberto Firmino both scored twice as Liverpool recorded their biggest away win in Europe in four years.
Jurgen Klopp's side were 5-1 winners away to Porto.
In last night's other Group B's other game, an injury time Luis Suarez penalty gave Atletico Madrid a 2-1 win away to AC Milan.
Twelve months after losing to Dundalk in the qualifying round of the Europa League, Sheriff produced the biggest shock of this year's Champions League.
The Moldovan champions went to the Bernabeu and beat Real Madrid 2-1.