6 personnel changes from Italy game; Doriis goes to No. 8
One win from the remaining two games could be enough for Ireland to win the Six Nations for the first time since 2019.
Scotland are in Ireland's World Cup pool, so Sunday's game at Murrayfield will be as much about setting down a marker.
Johnny Sexton, Garry Ringrose and Tadhg Furlong all return.
Prop Furlong makes his first appearances of the championship and his first competitive appearance since December, while out-half Sexton and centre Ringrose have recovered from injuries.
Andy Farrell has made six changes to the side that won in Rome, with Dan Sheehan starting at hooker, while Peter O’Mahony returns to the blindside.
Conor Murray takes Craig Casey's place with fit-again Jamison Gibson-Park on the bench. Robbie Henshaw is also in line for a first game of the tournament after recovering from a wrist injury and is named in the replacements.
The back three of Hugo Keenan, Mack Hansen and James Lowe is unchanged, while Bundee Aki moves to inside centre.
Andrew Porter is at loosehead prop, while, James Ryan and Iain Henderson continue their second row partnership.
Peter O'Mahony joins Josh van der Flier and No 8 Caelan Doris in the back row.