It happened on the N25 at Ballinalboola.
Gardai in Co Wexford are appealing for witnesses to a road crash in which a man was seriously injured.
A car left the road and struck a tree on the N25 at Ballinalboola near New Ross at around 11pm last night.
The occupants - two men in their 20s - were taken to Waterford University Hospital.
The driver is in a serious condition, while the passenger sustained non life threatening injuries.
The road has reopened and gardai are asking anyome who was in the area at the time to contact them.

€2 Million Transport Fund Announced to Support Learners with Disabilities
Fears Surround Potential Job Losses At Claire's Newbridge Store
Previously Paused Social Housing Project In Athy Gets Go-Ahead
Spike in Helpline Calls After Controversial Parade Float
Warmest Day Of The Year So Far As Temperatures Climb
Hollywood Comes To Rathangan
12th Lock To Hazelhatch Greenway Has Officially Opened
Banished Temple Bar St. Patrick Statue Makes Surprise Return in Kildare Parades