Helen McEntee and Simon Coveney earlier ruled themselves out.
Simon Harris is almost certain to be the next Fine Gael leader and Taoiseach.
He's expected to announce his candidacy after all his potential competitors announced they weren't running.
His main potential competitors have now all ruled themselves out of the race with Paschal Donohoe and Heather Humphries the latest to exclude themselves.
Helen McEntee and Simon Coveney earlier ruled themselves out.
It means Simon Harris will be the only contender for leader of Fine Gael barring a rogue backbencher or junior minister trying to get nominations.
Nominations will then officially close next Monday with the result due on April 5th.
After that, if everything goes to plan, Simon Harris would become Taoiseach the next time the Dail sits on April 9th.
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